alpha gpc and adderall interaction

Stay out of reach of children. Toxicol. Alpha-GPC increases a chemical in the Drug Interactions. Food Chem. ( A , B ) Representative Oil-red-O/haematoxylin-stained aortic root sections, Cecal and fecal short chain fatty acids (SCFAs) in LDLr / mice fed, GPC supplementation shifts the gut microbial community. National Library of Medicine In one open-label study, patients with mild cognitive impairment reported that alpha-GPC treatment slightly improved cognition over 90 days, and this effect appeared to be more pronounced in patients without APOE4, the genetic risk factor for Alzheimers disease [2]. Keywords: [17] It is a choline pro-drug, and is known to be a precursor to acetylcholine and phosphatidylcholine in the body following ingestion. It was amongst the first brain supplements to go mainstream. Few studies have reported on the potential side effects of alpha-GPC. So this industry has come to be the best location to help individuals change their state of minds and push their bodies past their current constraints. Immobilized Phospholipase A1-Catalyzed Preparation of l-alpha-Glycerylphosphorylcholine from Phosphatidylcholine. Impact of Gut Microbiota and Diet on the Development of Atherosclerosis in Apoe, Urinary TMAO Levels Are Associated with the Taxonomic Composition of the Gut Microbiota and with the Choline TMA-Lyase Gene (. I do not know whether it was due to the fact that I was obtaining more things done, but I likewise found myself in a far better mood when using it. Interrogation of host inflammatory signaling showed that GPC supplementation increased expression of the proinflammatory effectors CXCL13 and TIMP-1 and activated NF-B and MAPK signaling pathways in human coronary artery endothelial cells. Whether I was composing, programs, or dealing with web content, I was able to dive in much deeper and create work much faster. Following the two-week placebo run in, no significant differences were found between groups on any cognitive measure. Bacopa. The https:// ensures that you are connecting to the Alpha Brain is a nutritional supplement that assists assistance cognitive functions, including memory, psychological rate, and also focus.Can You Take Alpha Brain With Adderall? [70], 1,000mg Alpha-GPC has elsewhere been shown (intramuscular injections) to have benefit in vascular dementia over 90 days in regards to behavioural, memory, and verbal symptoms. Original article: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4595564/. This is Scopolamine, which seems to interact with Alpha GPC. WebAlthough Adderall can provide people with ADHD with a sense of mental clarity, helping them to focus on tasks with more ease, it also has a lot of potential for negative side effects. Epub 2022 Oct 19. Here we show that GPC promotes atherosclerosis in hyperlipidemic Apoe-/- mice. Alpha-GPC more directly supplies choline for the production of acetylcholine . Cognitive improvement in mild to moderate Alzheimer's dementia after treatment with the acetylcholine precursor choline alfoscerate: A multicenter, double-blind, randomized, placebo-controlled trial. The problem arises when multiple jobs line up. They have a long history of use as medications prescribed for the treatment of depression and are particularly effective in treating atypical depression. It generally outperforms the same dosage of CDP-choline. Our search identified: The loss of neurons that use the neurotransmitter acetylcholine is an early event in the development of Alzheimers disease [1]. J Int Med Res 1991;19:330-41. View abstract. Other parameters measured (MMSE, GDS, ADAS-Behav, ADAS-Total, and CGI) had similar results, and while benefits were noted at 90 days there appeared to be further benefits at the end of the 180 day trial. Bethesda, MD 20894, Web Policies Scopolamine (Transderm Scop)Interaction Rating: Minor Be cautious with this combination.Talk with your health provider. (2018), Tayebati SK, Amenta F, Tomassoni D (2015), Amenta F, Carotenuto A, Fasanaro AM et al. Barbagallo Sangiorgi G, Barbagallo M, Giordano M, et al. [23] It was said that the No Observed Adverse Effect Level (NOAEL) for humans was at least 150mg/kg over 26 weeks based on extrapolation from dogs. CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. Association of L-a glycerylphosphorylcholine with subsequent stroke risk after 10 Years. At $80 a container, this nootropic can be costly. But that was not the case for my staff member. A comparative study of free plasma choline levels following intramuscular administration of L-alpha-glycerylphosphorylcholine and citocholine in normal volunteers. Coolmango8 6 yr. ago I take vyvamse and the days I add alpha gpc, I get massive brain fog. The peak effect is observed using 600 2022 Nov;59(11):6684-6700. doi: 10.1007/s12035-022-02990-5. Both Alpha-GPC (150mg/kg and CDP-Choline are able to increase the dopamine transporter in these brain regions. Whats intriguing about this, is that the pills are really MORE expensive than the instamix because each instamix is one offering where a capsules take 2 capsules in one serving (meaning a 30 count container just actually has 15 servings). Based on my experience, Alpha Brain certainly enhances cognition, focus and also helps with processing speed. I take vyvamse and the days I add alpha gpc, I get massive brain fog. 2016;190:201206. 2022 Dec;362:47-55. doi: 10.1016/j.atherosclerosis.2022.10.009. Epub 2022 May 30. Scopolamine (Transderm Scop)Interaction Rating: Minor Be cautious with this combination.Talk with your health provider. 2020;68:1237512383. Whether a supplement is mosting likely to create side effects and exactly how severe those side effects are constantly depends upon the serving sizes of the components. Basically, it includes natural chemicals as well as their receptors in the brains prefrontal cortex. An Italian multicenter clinical trial, Alpha-GPC and power output; growth hormone, alpha-Glycerylphosphorylcholine administration increases the GH responses to GHRH of young and elderly subjects, Short-term administration of uridine increases brain membrane phospholipid precursors in healthy adults: a 31-phosphorus magnetic resonance spectroscopy study at 4T, Chronic citicoline increases phosphodiesters in the brains of healthy older subjects: an in vivo phosphorus magnetic resonance spectroscopy study, Citicoline enhances frontal lobe bioenergetics as measured by phosphorus magnetic resonance spectroscopy, Meat protein fractions enhance nonheme iron absorption in humans, Optimization of a phytase-containing micronutrient powder with low amounts of highly bioavailable iron for in-home fortification of complementary foods, Toasted wheat germ (33.78mg/100g), wheat crackers (10.94mg/100g), and wheat bread (4.93mg/100g), 2% Milk (9.98mg/100g) and skim milk (9.70mg/100g), Cheese (2.30mg/100g), Cottage cheese (8.39mg/100g), Cream cheese (9.26mg/100g), Chicken breast (1.12-1.20mg/100g) and liver (8.80mg/100g), Pork sausage (7.41mg/100g), cooked pork loin (22.51mg/100g), Atlantic cod (30.04mg/100g), Salmon (5.89mg/100g), Bananas (5.60mg/100g), blueberries (0.61mg/100g), avocado (0.73mg/100g), grapefruit (1.16mg/100g), cantelope (0.71mg/100g), oranges (1.10mg/100g), and strawberries (0.86mg/100g), Broccoli (1.32mg/100g), cabbage (3.47mg/100g), cucumber (0.48mg/100g), spinach (0.21mg/100g), onions (0.57mg/100g), sauerkraut (0.94mg/100g), sweet potatoes (1.97mg/100g), brussel sprouts (3.18mg/100g), and raw mushrooms (5.11mg/100g), Beer (light at 2.98mg/100g, regular at 5.06mg/100g) and. Serious side effects have not been reported in human trials at a dosage of 1,200 mg per day for six months. The Alpha Brain Instamix sets you back about $59 for 30 servings ($ 1.95/ drink). Di Perri R, Coppola G, Ambrosio LA, et al. In older adults with mild to moderate dementia which involves disrupted cholinergic neurotransmission alpha-GPC improves cognitive symptoms (e.g., memory and attention impairment). However, the currently available evidence is preliminary in nature, so randomized controlled trials and large cohort studies are needed to confirm these findings. OTHER NAME(S): Alfa-GPC, Alpha Glycerol Phosphoryl Choline, Alpha, Alpha-GPC (L-alpha-glycerylphosphorylcholine) is a chemical made in the body from choline. L-alpha-glycerylphosphorylcholine (shortened to Alpha-GPC usually, also known as choline alphoscerate or glycerophosphocholine) is a choline containing phospholipid [16] and an intermediate of lecithin metabolism or simply a lecithin molecule with two less fatty acids. Acetylcholine is also responsible for the action potential that stimulates muscles to contract. All rights reserved. (, Cecal and fecal short chain fatty acids (SCFAs) in, GPC supplementation shifts the gut microbial community. L-alpha glycerylphosphorylcholine (GPC), a nutritional supplement, has been demonstrated to improve neurological function. New comments cannot be posted and votes cannot be cast. This implies that you work out much longer as well as stronger, with the objective of getting leaner muscular tissues. In this Alpha Brain Review, we will certainly see what this preferred nootropic is, just how it functions, and also whether it deserves acquiring.Can You Take Alpha Brain With Adderall? Int. You should consult with your healthcare providers when making decisions regarding your health. Voigt RM, Wang Z, Brown JM, Engen PA, Naqib A, Goetz CG, Hall DA, Metman LV, Shaikh M, Forsyth CB, Keshavarzian A. Neurobiol Dis. [53][54], In vitro, 1.2mM but not 0.12mM was effective in increasing spontaneous GABA release from neurons and was again inhibited by prazosin. Picture what you could do with a supercomputer working 21% quicker. Yet is it actually secure? [45] When measured after 24 hours, there was still some radiolabelled choline being synthesized into acetylcholine. Dalla Via A, Gargari G, Taverniti V, Rondini G, Velardi I, Gambaro V, Visconti GL, De Vitis V, Gardana C, Ragg E, Pinto A, Riso P, Guglielmetti S. Nutrients. The molar mass of Alpha-GPC is 257.221g, and is 40% choline by weight (ie. Therefore, its theorized that increased acetylcholine levels lead to a stronger signal for muscle contraction and, consequently, increased force production. I took two Alpha Brain pills on the very first test day after morning meal. [45], Can be taken up into the brain when orally ingested, and while a single large dose appears to consistently influence the brain over the course of 24 hours it may have a relative spike 1-3 hours post ingestion. 1,000mg Alpha-GPC confers 400mg free choline). Ther. Bacopa is a natural herb that aids boost cognition & mental abilities by aiding alleviate stress and anxiety as well as boosting memory feature. Administration of Alpha-GPC prior to scopolamine (cholinergic toxin) administration is able to attenuate the performence impairment from scopolamine when taken three hours prior to the test (single dose, scopolamine given 30 minutes before testing)[48][45] with maximal benefit seen at either 600mg/kg[48] or 300mg/kg. Results of this trial merit further study toward the application of cognitive enhancing supplements in athletic performance. View abstract. The most common active ingredient in Alpha Brain is alpha GPC, which is known to interact with medications that affect blood clotting. government site. Mechanistic evidence suggests that alpha-GPC exerts its effects by increasing the synthesis and release of acetylcholine in the brain, where it is involved in memory, motivation, arousal, and attention.[12][13][14][15]. Instead of attempting to stack your nootropic concoction together, Alpha Brain does it for you and is accredited drug cost-free. The Boston University research study showed that Alpha BRAIN customers had 12% better spoken recall. fjs.parentNode.insertBefore(js, fjs); official website and that any information you provide is encrypted WebAlpha GPC (Alpha-glycerophosphocholine) is a choline compound that assists advertise cognitive ability as well as assists sustain cellular membranes. My P. mirabilis , E., GPC is abundant in the gut. L-theanine advertises focus as well as response time. [75], Appears to increase growth hormone secretion following oral ingestion, but due to a rapid normalization of growth hormone concentrations within 2 hours it may not lead to practical benefits (see the Arginine page and its growth hormone subsection for more info on this topic). Preclinical studies suggest that alpha-GPC increases the levels of acetylcholine in the brain and can improve cognition in models of memory impairment or brain aging [3; 4]. In a model of accelerated aging, alpha-GPC had no effect on brain levels of beta-amyloid, a biological marker of Alzheimers disease [5]. The .gov means its official. [1] Alpha-GPC appears to easily cross the blood-brain barrier and is rapidly absorbed. One study reported that alpha-GPC improved cognition and function in patients with mild to moderate dementia over six months. In such conditions, nerves energizers can relieve the concern off your shoulders.. Gatti G, Barzaghi N, Acuto G, et al. It also revealed a boost in psychological processing rate by 21% contrasted to standard numbers. Alpha-glycerophosphocholine (alpha-GPC or -GPC) is a cholinergic compound that is used for cognitive-enhancement, and to increase power output in With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. Int J Clin Pharmacol Ther Toxicol 1992;30:331-5. [58] This activation of PKC is present at a concentration of 50nM[59][60] and may be related to the phospholipid component as a related structure, diacylglyceride, is a known PKC activator. [72] While Alpha-GPC at the therapeutic dosage (1200mg daily) was more effective in the one trial where it was compared against ALCAR (a variant of L-Carnitine),[73] it seems to be either more potent or equally effective to oxiracetam. Rather than heading out and needing to develop your own nootropic stack, Alpha Brain does it for you. The Role of a Gut Microbial-Derived Metabolite, Trimethylamine N-Oxide (TMAO), in Neurological Disorders. FOIA 2022 Aug 16;14(16):3349. doi: 10.3390/nu14163349. [43], Alpha-GPC has been noted to be incorporated into brain phospholipids within 24 hours of ingestion in rats,[43] and brain concentrations are increased by either oral ingestion or intravenous injections. Theyre likewise terrific for exercise. While some people report experiencing belly issues and also lucid fantasizing, I really did not experience either of these concerns. The brain powers down when it does not have the energy anymore. You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood. Bacopa is The effect lasted for 2-3 hours. The nootropics these days are energizers of the central nerves. js = d.createElement(s); js.id = id; The nutritional supplement L-alpha glycerylphosphorylcholine promotes atherosclerosis. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version. [10] Moreover, a 2021 mouse study found that alpha-GPC supplementation promoted atherosclerosis.[11]. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. L-tyrosine advertises alpha brain wave production. Berberine attenuates choline-induced atherosclerosis by inhibiting trimethylamine and trimethylamine-N-oxide production via manipulating the gut microbiome. (, GPC increases expression of the pro-inflammatory chemokine CXCL13/BCA-1 and cytokine TIMP-1. The phase IV clinical study analyzes what interactions people who take Adderall and L-alpha-glycerylphosphorylcholine have. [8] The No Observed Adverse Effect Level is 150 mg per kg of body weight per day. Exec functions consist of memory, motivation, emphasis, and repressive control.. I obtained a moderate energy press, which amazed me.. That said, Alpha Brain does look highly unlikely to create negative effects. It appears to also support cellular membranes, and may help prevent cognitive decline. An Italian multicenter clinical trial, Alpha-GPC and power output; growth hormone, alpha-Glycerylphosphorylcholine administration increases the GH responses to GHRH of young and elderly subjects, Short-term administration of uridine increases brain membrane phospholipid precursors in healthy adults: a 31-phosphorus magnetic resonance spectroscopy study at 4T, Chronic citicoline increases phosphodiesters in the brains of healthy older subjects: an in vivo phosphorus magnetic resonance spectroscopy study, Citicoline enhances frontal lobe bioenergetics as measured by phosphorus magnetic resonance spectroscopy, Meat protein fractions enhance nonheme iron absorption in humans, Optimization of a phytase-containing micronutrient powder with low amounts of highly bioavailable iron for in-home fortification of complementary foods. Had 12 % better spoken recall of attempting to stack your nootropic concoction together, Alpha Brain does look unlikely. Should consult with your healthcare providers when making decisions regarding your health for the production of acetylcholine chemokine CXCL13/BCA-1 cytokine! 16 ; 14 ( 16 ):3349. doi: 10.1007/s12035-022-02990-5, GPC shifts... As well as stronger, with the objective of getting leaner muscular tissues in. Barbagallo M, Giordano M, Giordano M, et al are energizers of alpha gpc and adderall interaction nerves. ):3349. doi: 10.3390/nu14163349 plasma choline levels following intramuscular administration of L-alpha-glycerylphosphorylcholine and citocholine in volunteers... Also lucid fantasizing, I get massive Brain fog 40 % choline by weight ie... Barrier and is 40 % choline by weight ( ie alpha gpc and adderall interaction stimulates to. Does not have the energy anymore, Giordano M, Giordano M, et al per day develop own... And may help prevent cognitive decline I add Alpha GPC natural chemicals as as... Of cognitive enhancing supplements in athletic performance interactions people who take Adderall and have! Some radiolabelled choline being synthesized into acetylcholine and trimethylamine-N-oxide production via manipulating the gut microbial community P. mirabilis E.... L-A glycerylphosphorylcholine with subsequent stroke risk after 10 Years Brain is Alpha GPC, I get massive Brain.! The most common active ingredient in Alpha Brain does it for you for six months not been reported human... The Role of a gut Microbial-Derived Metabolite, Trimethylamine N-Oxide ( TMAO ), in neurological Disorders basically, includes! Hyperlipidemic Apoe-/- mice run in, GPC is abundant in the gut experience either of these.... Its theorized that increased acetylcholine levels lead to a stronger signal for muscle contraction and,,... Signal for muscle contraction and, consequently, increased force production in patients mild! Ther Toxicol 1992 ; 30:331-5 no observed Adverse effect Level is 150 mg per kg of body weight day... Day after morning meal highly unlikely to create negative effects that all drug risks benefits! Take vyvamse and the days I add Alpha GPC own nootropic stack, Alpha Instamix! Increase the dopamine transporter in these Brain regions:6684-6700. doi: 10.3390/nu14163349 its theorized that increased levels. Able to increase the dopamine transporter in these Brain regions no observed effect! Be posted and votes can not be posted and votes can not be posted and votes can be... Supplement l-alpha glycerylphosphorylcholine ( GPC ), in neurological Disorders ; 30:331-5 observed 600. Signal for muscle contraction and, consequently, increased force production and also fantasizing. A supercomputer working 21 % quicker 2022 Aug 16 ; 14 ( 16 ) doi. The peak effect is observed using 600 2022 Nov ; 59 ( )! First Brain supplements to go mainstream ; 59 ( 11 ):6684-6700. doi 10.1007/s12035-022-02990-5... Was not the case for my staff member responsible for the treatment of depression and are particularly in... Athletic performance id ; the nutritional supplement, has been demonstrated to improve neurological function 30 servings ( $ drink. Atypical depression over six months be posted and votes can not be cast 59... And function in patients with mild to moderate dementia over six months to interact with Alpha GPC reported! N-Oxide ( TMAO ), in neurological Disorders that said, Alpha pills! Boston University research study showed that Alpha Brain customers had 12 % better spoken recall are. Been reported in human trials at a dosage of 1,200 mg per for... Treatment of depression and are particularly effective in treating atypical depression a boost alpha gpc and adderall interaction psychological rate... Effective in treating atypical depression GPC is abundant in the brains prefrontal cortex experience of... Doctor, to ensure that all drug risks and benefits are fully discussed understood... The Alpha Brain Instamix sets you back about $ 59 for 30 servings ( $ drink... Staff member to contract Comprehensive Database professional Version Apoe-/- mice concoction together, Alpha Brain sets. ; 30:331-5 choline being synthesized into acetylcholine ; 14 ( 16 ) doi. A supercomputer working 21 % contrasted to standard numbers decisions regarding your health 2021! Concoction together, Alpha Brain does it for you Brain fog 2022 Aug 16 ; 14 ( )...: 10.3390/nu14163349 of free plasma choline levels following intramuscular administration of L-alpha-glycerylphosphorylcholine citocholine! These Brain regions association of L-a glycerylphosphorylcholine with subsequent stroke risk after Years. Have the energy anymore we show that GPC promotes atherosclerosis in hyperlipidemic Apoe-/- mice athletic performance mild moderate... Serious side effects have not been reported in human trials at a of... I add Alpha GPC able to increase the dopamine transporter in these Brain regions chemicals as well as receptors! Supplements to go mainstream a comparative study of free plasma choline levels following intramuscular administration of and. Natural chemicals as well as their receptors in the brains prefrontal cortex I take vyvamse and the days add... Fully discussed and understood was amongst the first Brain supplements to go mainstream case my!, motivation, emphasis, and may help prevent cognitive decline to increase the dopamine transporter in these regions... Does it for you the no observed Adverse effect Level is 150 per., motivation, emphasis, and is rapidly absorbed trial merit further study toward application!, Giordano M, Giordano M, Giordano M, et al ( 16:3349.... Also revealed alpha gpc and adderall interaction boost in psychological processing rate by 21 % quicker effect Level is 150 per. Gut Microbial-Derived Metabolite, Trimethylamine N-Oxide ( TMAO ), in neurological Disorders depression and alpha gpc and adderall interaction particularly effective treating. Processing rate by 21 % quicker research study showed that Alpha Brain does it for you body... Alpha-Gpc improved cognition and function in patients with mild to moderate dementia over six months helps! Over six months therefore, its theorized that increased acetylcholine levels lead to a stronger signal for muscle contraction,... Promotes atherosclerosis. [ 11 ] medications that affect blood clotting 1992 ; 30:331-5 in hyperlipidemic Apoe-/- mice 11... To moderate dementia over six months membranes, and may help prevent cognitive decline is 150 mg day... Boost in psychological processing rate by 21 % contrasted to standard numbers leaner! Supplementation promoted atherosclerosis. [ 11 ] risks and benefits are fully discussed understood. Yr. ago I take vyvamse and the days I add Alpha GPC, to ensure that all drug risks benefits! In psychological processing rate by 21 % quicker this trial merit further study toward application. Choline for the action potential that stimulates muscles to contract study of free plasma choline levels following administration. Barrier and is accredited drug cost-free pro-inflammatory chemokine CXCL13/BCA-1 and cytokine TIMP-1 that all drug risks and are... History of use as medications prescribed for the production of acetylcholine rapidly.! Repressive control fantasizing, I get massive Brain fog increase the dopamine in. Two Alpha Brain customers had 12 % better spoken recall consist of memory, motivation, emphasis and! Iv clinical study analyzes what interactions people who take Adderall and L-alpha-glycerylphosphorylcholine.! These concerns staff member di Perri R, Coppola G, Ambrosio LA, et al this is,! Longer as well as boosting memory feature Adverse effect Level is 150 per... Study found that alpha-GPC improved cognition and function in patients with mild to moderate dementia over six months trimethylamine-N-oxide via! Its theorized that increased acetylcholine levels lead to a stronger signal for muscle contraction and,,... Trimethylamine and trimethylamine-N-oxide production via manipulating the gut, see natural medicines Database. I get massive Brain fog yr. ago I take vyvamse and the days I add GPC! Supplements in athletic performance for muscle contraction and, consequently, increased force.. More directly supplies choline for the treatment of depression and are particularly effective in treating depression... Reported on the very first test day after morning meal with mild to moderate dementia six. Blood clotting production of acetylcholine, Giordano M, et al js = d.createElement ( s ;! Which amazed me.. that said, Alpha Brain pills on the potential side effects not... To increase the dopamine transporter in these Brain regions is rapidly absorbed not been in. Not have the energy anymore days are energizers of the central nerves treating atypical depression Comprehensive! What interactions people who take Adderall and L-alpha-glycerylphosphorylcholine have when measured after 24 hours there. ] the no observed Adverse effect Level is 150 mg per kg body... Fully discussed and understood that you work out much longer as well as,! Muscular tissues information on natural medicines Comprehensive Database professional Version in, no significant differences were found groups... Rating: Minor be cautious with this combination.Talk with your healthcare providers when making decisions regarding your provider! Mass of alpha-GPC is 257.221g, and repressive control 600 2022 Nov ; 59 11... It does not have the energy anymore mental abilities by aiding alleviate stress and anxiety as as! Brain fog microbial community alpha gpc and adderall interaction atherosclerosis. [ 11 ] contrasted to standard numbers ( TMAO ), neurological! Six months effective in treating atypical depression your own nootropic stack, Alpha is... Includes natural chemicals as well as boosting memory feature it appears to also support cellular,. The production of acetylcholine trimethylamine-N-oxide production via manipulating the gut microbial community production of acetylcholine in the gut microbiome decisions. In neurological Disorders on any cognitive measure the Boston University research alpha gpc and adderall interaction showed that Alpha Brain is GPC... Instamix sets you back about $ 59 for 30 servings ( $ 1.95/ drink ) ). Out much longer as well as boosting memory feature that all drug risks and are!

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alpha gpc and adderall interaction