pfizer vaccine becomes dna in liver

In the cell line in a petri dish, you dont have those checks in place.. MR: We understood that the study would attract attention, but we think it is self-evident that this type of research should be pursued. Rasmussen also said, cell lines differ from cells in living organisms, and therefore it is important that similar investigations are also studied in humans.. The paper was published in April 2020, which was very early during the pandemic. Finally, as the authors pointed out, expression of LINE-1 has been shown to increase during viral infections, including with SARS-CoV-2 virus. And, notably, there didnt appear to be a control group for the hep B vaccine Siri says. WebFew vaccines have been launched for this purpose recently with different side effects. Drugs and vaccines used for treating and preventing coronavirus infection also have hepatotoxicity. The Centers for Disease Control and The study authors clarified their research in a Q&A in March after it received significant attention, stating this study does not investigate whether the Pfizer vaccine alters our genome, and that there is no reason for anyone to change their decision to take the vaccine based on this study.. WebDid your doctor explain the difference between a traditional vaccine and a MRNA gene therapy to you? Magnus Rasmussen But studies are showing that is not the case. This would be like saying that two people have the same social security number because both contain the number 5. Cells that received no vaccine at all were used for control purposes.The researchers then investigated how different gene expressions in the cells changed over time. YDM: One of the limitations of our study is that we dont know if what we observed in this cell line could also happen in cells of other tissue types, and this needs to be addressed in follow-up studies. Before And, this month, we saw a few of the many ways that science can be misinterpreted and misused. An important thing to notice when looking at this figure is that unlike most axis numbers, those on the y-axis showing cycle threshold are decreasing in number as they go higher on the graph. ADE is a condition in which the antibodies against a pathogen increase the ability of the pathogen to get into cells. Likewise, proteins from pathogens are sometimes going to share similar stretches with our proteins as well. 2022 Oct 21;13:475. doi: 10.25259/SNI_377_2022. Unable to load your collection due to an error, Unable to load your delegates due to an error. This is the first time that researchers have shown in vitro or inside a petri dish how an mRNA vaccine is converted into DNA on a human liver cell line, and is what health experts and fact-checkers said for over a year couldnt occur. Intracellular Reverse Transcription of Pfizer BioNTech COVID-19 mRNA Vaccine BNT162b2 In Vitro in Human Liver Cell Line. Based on this study, is there any reason to not get vaccinated? It is important to bear in mind that the liver cells in this study are more genetically unstable than our own liver cells. "LINE-1 can convert RNA to DNA and has been shown to be found in tissues, including stem cells, in the human body. This is 1 replication competent plasmid per 350 mRNA molecules and equates to billions of antibiotic resistant plasmids injected per person per shot . This means that what is seen in these cells may not be representative of what would happen in non-cancerous liver cells (or even a different line of cancerous liver cells). N. Engl. 2020 Apr 9;3:100051. WebThe interaction between pre-existing liver disease and coronavirus infection has been illustrated, whereby coronaviruses influence the occurrence, severity, prognosis and treatment of liver diseases. PCR primer set used to detect mRNA level and reverse-transcription of BNT162b2. Currently the Pfizer-Biontech (mRNA), Sinovac (inactivated virus) and Astrazeneca-Oxford (adenovirus-vector) COVID-19 vaccines are available for vaccination in HK. Huh7 cells were treated, Immunohistochemistry of Huh7 cells treated, Immunohistochemistry of Huh7 cells treated with BNT162b2 on LINE-1 protein distribution. Nucleic acid vaccines: These vaccines use genetic materialDNA or mRNAmade in a lab to trigger an immune response. 5 Notably, mutations in the BRCA tumor-suppressor genes can be inherited. These vaccines deliver genetic material that instructs cells to begin making spike proteins found on the surface of SARS-CoV-2 that causes COVID-19 to produce an immune response. Click here to sign in with The authors declare no conflict of interest. in Scientists estimate that the spike protein, like other proteins our bodies create, may stay in the body up to a few weeks., Further, the CDC says on a web page titled Myths and Facts about COVID-19 Vaccines that the genetic material delivered by mRNA vaccines never enters the nucleus of your cells.. The vaccines mRNA converting into DNA and being found inside the cells nucleus is something that the Centers for Disease Control and Prevention (CDC) said would not happen. Mitogen Activated Protein Kinase (MAPK) Activation, p53, and Autophagy Inhibition Characterize the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Spike Protein Induced Neurotoxicity. Daily science news on research developments and the latest scientific innovations, The latest engineering, electronics and technology advances, The most comprehensive sci-tech news coverage on the web. In the case of Covid shots, the vaccines from Moderna and Pfizer ( PFE )/BioNTech introduce a single spike protein. The views expressed in this article are those of the author and do not reflect the official position of yourNEWS. in petri dishes, the researchers added Pfizer BioNTech's vaccine to a cell line that originally came from a human liver tumour. Greece leads the car sales race in the EU! Tozinameran (BNT162b2) Vaccine: The Journey from Preclinical Research to Clinical Trials and Authorization. Our bodies also have tens, if not hundreds, of thousands of different proteins. 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Two people in their 60s who received the shot were diagnosed with Guillain-Barre syndrome, out of about 20,000 vaccine recipients who participated in Pfizers Phase 3 Experts say additional research is needed because the findings in the lab setting cannot be used to make inferences about what might happen in a human body. BNT162b2 mRNA is reverse transcribed intracellularly into DNA as fast as 6 [hours] after BNT162b2 exposure.. In the case of Covid shots, the vaccines from Moderna and Pfizer /BioNTech introduce a single spike protein. :\rBuy me a coffee :-) https://www.buymeacoffee.com/DrMobeenSyed\rBecome my patron: https://www.patreon.com/mobeensyed?fan_landing=true\rPayPal: https://paypal.me/mobeensyed?locale.x=en_US\r\r#drbeen #koolbeens #COVID\r\rDisclaimer:\rThis video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. Shakira. It has also been shown to affect immune responses. They are not sure if it gets integrated in our DNA or not. The site is secure. But keep in mind, when the mRNA or adenovirus particles do hit cells outside of the liver or the site of injection, they're still causing them to express Spike protein anchored on their surfaces, not dumping it into the circulation. RNA levels of BNT162b2 are presented as logged 2, Immunohistochemistry of Huh7 cells treated with BNT162b2 on LINE-1 protein distribution. because Pfizer doesn't have any good studies on intra-cellular toxicity of their vaccine .. it leaves behind genetic markers that may indicate a change in DNA of the This site needs JavaScript to work properly. 3401 Civic Center Blvd. You should not consider the information in this site to be specific, professional medical advice for your personal health or for your family's personal health. 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Our publication is the first in vitro study on the conversion of mRNA vaccine into DNA, inside cells of human origin. Get weekly and/or daily updates delivered to your inbox. According to Swedish researchers at Lund University, the messenger mRNA from Pfizers Covid vaccine can enter human liver cells and is converted into DNA. -, Polack F.P., Thomas S.J., Kitchin N., Absalon J., Gurtman A., Lockhart S., Perez J.L., Perez Marc G., Moreira E.D., Zerbini C., et al. This, of course, does not mean these data are not important. Yau K, Chan CT, Abe KT, Jiang Y, Atiquzzaman M, Mullin SI, Shadowitz E, Liu L, Kostadinovic E, Sukovic T, Gonzalez A, McGrath-Chong ME, Oliver MJ, Perl J, Leis JA, Bolotin S, Tran V, Levin A, Blake PG, Colwill K, Gingras AC, Hladunewich MA. We show that the vaccine enters liver cells as early as 6 hours after the vaccine has been administered. The dots are placed based on the day of illness (x-axis) and something called cycle threshold, which is a measure of the number of cycles in PCR that it took to detect viral RNA (y-axis). If you dont have time (or interest) in reviewing the primary source of the information, it is often best to let the information die in your feed or your inbox. Study: Pfizer Covid Vaccine Converts to DNA Inside Liver Cells. The mean time from COVID-19 diagnosis to cholangiopathy was 118 days. doi: 10.7759/cureus.32361. It takes time and a significant accumulation of evidence to confirm them. A gene that the researchers studied produces the protein LINE-1. The posts share articles such as ones archived (here) and (here) saying the study, which was published in the Current Issues in Molecular Biology, shows mRNA from the Pfizer COVID-19 vaccine can enter human liver cells and convert to DNA as quickly as six hours after receiving a dose. MR: The study was performed on human liver cells from one cell line cell cultures used for research purposes. Does the Pfizer-BioNTech mRNA vaccine get converted to DNA or not? However, the researchers at Lund University in Malm, Sweden, found that the mRNA vaccine enters human liver cells and triggers the cells DNA in the nucleus to increase the production of the LINE-1 gene expression to make mRNA. Knowing that it is theoretically possible for RNA from a virus or RNA from a vaccine to be incorporated into a cell line in a test tube is very, very different from knowing whether that cell would then survive the bodys immune system and if it did survive the bodys immune system, would make any difference, Strain said. The results found that the vaccine intracellularly integrates into a persons DNA in a process that can happen within six hours of exposure. In adifferent study, the spike proteins made in the body after receiving a Pfizer COVID-19 shot have been found on tiny membrane vesicles called exosomesthat mediate cell-to-cell communication by transferring genetic materials to other cellsfor at least four months after the second vaccine dose. hasty generalization and appeal to ignorance. Organisation number: 202100-3211, Webmail Our monetization model empowers Citizen Journalists to report the news in local and national markets. Webhttps://lnkd.in/dSz2cbQJ This was what everyone told me would not happen- that the RNA vaccines would not go into the DNA! Read more about our fact-checking work here . If you take just one thing away from this series, we hope you will have come to realize that science does not easily fit into a sound bite and, most often, it is not an either-or proposition, so if something sounds too simple, you probably need to ask more questions. , ! Finally, protein shapes change in different environments, so while it may be interesting to compare in which parts of the body these proteins with similar stretches are located, we cant really know whether cross-reactivity would be an issue simply by comparing the gene sequences or even by working with the proteins on the lab bench. Once the string of amino acids is created in the cell, chemical and physical forces, such as the charges and shapes of the amino acids in the sequence as well as other factors in the cellular environment, cause the newly formed protein to fold into a 3D shape. is the set of instructions to build and sustain a human being. Missing context. The authors said more investigations are needed, including in whole living organisms such as animals, to better understand the potential effects of the mRNA vaccine. Two years later, we have ample evidence that previously infected or previously vaccinated people do not get more severely ill. A look at the authors affiliation and declaration of competing interest as well as an online search of his name and place of employment indicate that he probably has an anti-vaccine bias. The Swedish study suggests the vaccine is capable of becoming DNA, which is what the CDC claimed In this study, we investigated the effect of BNT162b2 on the human liver cell line Huh7 in vitro. Rasmussen explained in the article that there was no reason to change the decision to receive a vaccine based on the study. No information in this video should ever be considered as a substitute for advice from a healthcare professional.\r\rURL list from Friday, Feb. 25 2022\r\rCIMB | Free Full-Text | Intracellular Reverse Transcription of Pfizer BioNTech COVID-19 mRNA Vaccine BNT162b2 In Vitro in Human Liver Cell Line | HTML\rhttps://www.mdpi.com/1467-3045/44/3/73/htm\r\rFrontiers | Identification of Characteristic Genomic Markers in Human Hepatoma HuH-7 and Huh7.5.1-8 Cell Lines | Genetics\rhttps://www.frontiersin.org/articles/10.3389/fgene.2020.546106/full#:~:text=HuH%2D7%20(hereafter%20Huh7),experimental%20substitute%20for%20primary%20hepatocytes.\r\rURL list from Monday, Feb. 28 2022\r\rCIMB | Free Full-Text | Intracellular Reverse Transcription of Pfizer BioNTech COVID-19 mRNA Vaccine BNT162b2 In Vitro in Human Liver Cell Line | HTML\rhttps://www.mdpi.com/1467-3045/44/3/73/htm\r\rLINE-1 protein localization and functional dynamics during the cell cycle | eLife\rhttps://elifesciences.org/articles/30058\r\rTime evolution of PEG-shedding and serum protein coronation determines the cell uptake kinetics and delivery of lipid nanoparticle formulated mRNA | bioRxiv\rhttps://www.biorxiv.org/content/10.1101/2021.08.20.457104v1\r\rReverse-transcribed SARS-CoV-2 RNA can integrate into the genome of cultured human cells and can be expressed in patient-derived tissues - PubMed\rhttps://pubmed.ncbi.nlm.nih.gov/33958444/\r\rNo evidence of SARS-CoV-2 reverse transcription and integration as the origin of chimeric transcripts in patient tissues - PMC\rhttps://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC8379926/\r\rOverview of Reverse Transcription - Retroviruses - NCBI Bookshelf\rhttps://www.ncbi.nlm.nih.gov/books/NBK19424/\r\rNuclear pore blockade reveals that HIV-1 completes reverse transcription and uncoating in the nucleus | Nature Microbiology\rhttps://www.nature.com/articles/s41564-020-0735-8\r\rChimeric RNA - Wikipedia\rhttps://en.wikipedia.org/wiki/Chimeric_RNA\r\rBenchtop Automation for Immunohistochemistry (IHC), ISH \u0026 Special Stains (SS) - NanoMtrx 300 - YouTube\rhttps://www.youtube.com/watch?v=3IRl0kbR9-o\u0026ab_channel=BioGenexLaboratories\r\rSchrdinger's cat - Wikipedia\rhttps://en.wikipedia.org/wiki/Schr%C3%B6dinger%27s_cat Social security number because both contain the number 5, including with SARS-CoV-2.! 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pfizer vaccine becomes dna in liver